RealityGrid exploits a Grid infrastructure consisting of the full UK National Grid Service NGS, including its supercomputing resources at HPCx and CSAR, and the US TeraGrid through NSF (National Science Foundation), NRAC (National Research Allocation Committee) and PACI (National Science Foundation's Partnership for Advanced Computational Infrastructure) grants. Both the NGS and the TeraGrid use the Globus Toolkit middleware.

This trans-Atlantic federated Grid provides unparalleled computational power in a coordinated and coherent fashion; this enables the heterogenous and geographically distributed resources to be marshalled in service of a single scientific problem. The use of advanced optically switched lightpaths, for both intra and inter-Grid transfer, makes such federation worthwhile. High bandwidth, low latency connection between the UK and US Grid resources is provided by UKLight circuit-switched networks in the context of the EPSRC/ PPARC/ MRC funded Exploitation of Switched Lightpaths For E-Science Applications (ESLEA) project.

Click here for an example of the Grid infrastructure as used by the SPICE project.

RealityGrid is also designated as part of the Joint Research Activity for material sciences in DEISA (Distributed European Infrastructure for Supercomputing Applications).
The RealityGrid proposal LIAMS (Large-scale Intensive Applications of Molecular Simulations) is one of the projects retained for operation in the first European Call for Proposals of the DEISA Extreme Computing Initiative, for simulations that can take advantage of the DEISA Grid.